Cannabinoid type 2 receptor (CB2R) distribution in dermatomyositis skin and peripheral blood mononuclear cells (PBMCs) and in vivo effects of Lenabasum TM .
Spandana MaddukuriJay R PatelDe Anna DiazKristen L ChenMaria WysockaChristina E BaxDian-Wen JuAdarsh RavishankarMadison GrinnellMajid ZeidiNithin ReddyJosef Symon S ConchaMuhammad M BashirJoyce OkawaBarbara WhiteVictoria P WerthPublished in: Arthritis research & therapy (2022)
Our findings of differential CB2R expression based on location and cell type suggest modes by which lenabasum may exert anti-inflammatory effects in DM and highlights dendritic cells as potential therapeutic targets.