Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis.

Fumika HondaHiroto TsuboiYuko OnoSaori AbeHiroyuki TakahashiKiyoaki ItoKazunori YamadaMitsuhiro KawanoYuya KondoKenichi AsanoMasato TanakaMarie MalissenBernard MalissenIsao MatsumotoTakayuki Sumida

Published in: Arthritis research & therapy (2021)

We clarified the overexpression and therapeutic potential of the mouse CCL8-CCR8 axis in LAT mice, which could play a crucial role in fibrosis via ERK1/2 phosphorylation, as well as the chemotaxis of inflammatory cells. The human CCL18-CCR8 axis might be a novel therapeutic target for IgG4-RD.

Keyphrases

liver fibrosis
dendritic cells
regulatory t cells
liver injury
induced apoptosis
cell proliferation
endothelial cells
signaling pathway
drug induced
type diabetes
skeletal muscle
pi k akt
immune response
endoplasmic reticulum stress
pluripotent stem cells
protein kinase