Non-bacterial cystitis with increased expression of programmed death-ligand 1 in the urothelium: An unusual immune-related adverse event during treatment with pembrolizumab for lung adenocarcinoma.

Yohei UekiMasahiro MatsukiTerufumi KuboRena MoritaYoshihiko HirohashiSyunsuke SatoRyota HoribeKazuhiko MatsuoTomohide TsukaharaTakayuki KanasekiYasunari TakakuwaMasaaki SatohNaoki ItohToshihiko Torigoe

Published in: IJU case reports (2020)

Immune checkpoint inhibitors-induced cystitis is extremely rare. This report is the first to include an immunohistochemical analysis of the urothelial epithelium in immune-related adverse event cystitis and describes an instructive case.

Keyphrases

poor prognosis
drug induced
high glucose
emergency department
diabetic rats
binding protein
endothelial cells
stress induced