Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3.
Woo Yong ParkJinbong ParkKwang Seok AhnHyun Jeong KwakJae-Young UmPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2021)
To determine whether ellagic acid (EA) induces the "beige remodeling" of white adipose tissue (WAT), we treated cold-exposed mice and mouse stromal vascular fraction (SVF) cells with EA, a phytochemical abundant in fruits and vegetables, in particular berries. We then investigated the mechanism of EA in beige remodeling with a particular focus on DRP1-mediated mitochondrial fission and SIRT3. EA induced the trans-differentiation of white adipocytes to beige adipocytes by promoting the expression of UCP1 and other brown and beige adipocytes/fat factors (PRDM16, UCP1, PGC1α, CD137, and TBX1) and mitochondrial dynamics-related factors (SIRT3, NRF1, CPT1β, DRP1, and FIS1) in 3T3-L1/SVF cells, and these were confirmed in the inguinal WAT of a cold-exposed mouse model. The browning effect of EA was abolished by a potent DRP1 inhibitor Mdivi-1 or SIRT3 knockdown, suggesting that EA induces beige remodeling of WAT by regulating the mitochondrial dynamics and SIRT3.
Keyphrases
- oxidative stress
- adipose tissue
- induced apoptosis
- diabetic rats
- ischemia reperfusion injury
- insulin resistance
- high fat diet induced
- high fat diet
- mouse model
- cell cycle arrest
- poor prognosis
- bone marrow
- skeletal muscle
- cell death
- signaling pathway
- metabolic syndrome
- high resolution
- atomic force microscopy
- drinking water
- nk cells
- health risk
- high speed