Growth hormone/IGF-1 axis longitudinal evaluation in clinically isolated syndrome patients on interferon β-1b therapy: stimulation tests and correlations with clinical and radiological conversion to multiple sclerosis.

Roberta LanzilloC Di SommaMario QuarantelliA CarotenutoC PivonelloMarcello MocciaA CianfloneA MarsiliG PuorroF SaccàC V RussoC De Luca PicioneF AusielloA ColaoV Brescia Morra

Published in: European journal of neurology (2016)

Growth hormone/IGF-1 axis function was found to be frequently altered in CIS patients, but this was not related to MS conversion. Patients experienced an improvement of GHD during IFN therapy. Longer follow-up is necessary to assess its impact on disease progression.

Keyphrases

multiple sclerosis
end stage renal disease
growth hormone
ejection fraction
chronic kidney disease
prognostic factors
stem cells
dendritic cells
patient reported outcomes
bone marrow
cross sectional
case report
binding protein
cell therapy