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Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.

Ekaterina V BelotserkovskayaVasily GolotinBurhan UyanikOleg N Demidov
Published in: Cell death discovery (2023)
Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon - clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease's development in old age.
Keyphrases
  • genome wide
  • induced apoptosis
  • randomized controlled trial
  • bone marrow
  • small molecule
  • cell cycle arrest
  • single cell
  • cell death
  • high throughput
  • oxidative stress
  • dna methylation
  • drug induced
  • bioinformatics analysis