Integrated Network Pharmacology and Gut Microbiota Analysis to Explore the Mechanism of Sijunzi Decoction Involved in Alleviating Airway Inflammation in a Mouse Model of Asthma.
Wenqing JiaChengling XuTong ZhaoQiuyang FanBo QiaoYueying WuJiali YuanJing ChenPublished in: Evidence-based complementary and alternative medicine : eCAM (2023)
SJZD alleviated the airway inflammation state in asthmatic mice. The findings suggest that increasing the relevant abundance of beneficial intestinal bacteria in mice with asthma, regulating intestinal flora, interfering with the level of TLR2 and TLR7 expression to adjust the secretion of inflammatory factors, and alleviating asthmatic airway inflammation may be the possible mechanism involved in the treatment of asthma by SJZD, providing a basis for further studies on SJZD.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- mouse model
- toll like receptor
- allergic rhinitis
- cystic fibrosis
- inflammatory response
- air pollution
- immune response
- high fat diet induced
- poor prognosis
- oxidative stress
- type diabetes
- long non coding rna
- microbial community
- metabolic syndrome
- adipose tissue
- antibiotic resistance genes
- smoking cessation