Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.
Luca A LottaRobert A ScottStephen J SharpStephen BurgessJian'an LuanTherese TillinAmand Floriaan SchmidtFumiaki ImamuraIsobel D StewartJohn R B PerryLuke MarneyAlbert KoulmanEdward D KarolyNita G ForouhiRasmus J O SjögrenNäslund ErikJuleen R ZierathAnna KrookDavid B SavageJulian L GriffinNishi ChaturvediAroon D HingoraniKay-Tee KhawInês BarrosoMark I McCarthyStephen O'RahillyNicholas J WarehamClaudia LangenbergPublished in: PLoS medicine (2016)
Evidence from this large-scale human genetic and metabolomic study is consistent with a causal role of BCAA metabolism in the aetiology of type 2 diabetes.