The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals.
Jean-Eudes FahrnerImran LahmarAnne-Gaëlle GoubetYacine HaddadAgathe CarrierMarine MazzengaDamien DrubayCarolina Alves Costa Silvanull nullEric de SousaCassandra ThelemaqueCléa MelenotteAgathe DubuissonArthur GeraudGladys FerrereRoxanne BirebentCamille BigenwaldMarion PicardLuigi CerboneJoana R LériasAriane LaparraAlice Bernard-TessierBenoît KloecknerMarianne GazzanoFrançois-Xavier DanlosSafae TerrisseEugenie PizzatoCaroline FlamentPierre LyEric TartourNadine BenhamoudaLydia MezianiAbdelhakim Ahmed-BelkacemMakoto MiyaraGuy GorochovFabrice BarlesiAlexandre TrubertBenjamin UngarYeriel EstradaCaroline PradonEmmanuelle GalloisFanny PommeretEmeline ColombaPernelle LavaudMarc DelogerNathalie M DroinEric DeutschBertrand GachotJean-Philippe SpanoMansouria MeradFlorian ScottéAurélien MarabelleFrank GriscelliJean Yves BlayJean-Charles SoriaMiriam MeradFabrice AndreJuliette VillemonteixMathieu F ChevalierSophie Caillat-ZucmanFlorence FenollarEmma Guttman-YasskyOdile LaunayGuido KroemerBernard La ScolaMarkus MaeurerLisa DerosaLaurence ZitvogelPublished in: Cancer discovery (2022)
This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike. See related commentary by McGary and Vardhana, p. 892. This article is highlighted in the In This Issue feature, p. 873.