Novel somatic alterations in unicentric and idiopathic multicentric Castleman disease.

Aaron M GoodmanAh-Reum JeongAlexis PhillipsHuan-You WangEthan S SokolPhilip R CohenJason SicklickDavid C FajgenbaumRazelle Kurzrock

Published in: European journal of haematology (2021)

We report 4 novel somatic alterations found in patients with UCD or iMCD. The 1q21 locus contains IL-6R, and duplication of this locus may increase IL-6 expression. These findings suggest that a clonal process may be responsible for the inflammatory phenotype in some patients with UCD and iMCD.

Keyphrases

copy number
poor prognosis
genome wide association study
oxidative stress
binding protein
dna methylation
genome wide