The Potential Effects of Isoleucine Restricted Diet on Cognitive Impairment in High-Fat-Induced Obese Mice via Gut Microbiota-Brain Axis.
Yuli WangXue RongHui GuanFangxin OuyangXing ZhouFeng LiXintong TanDapeng LiPublished in: Molecular nutrition & food research (2023)
Isoleucine restriction may be a potential intervention to reduce HFD-induced cognitive impairment by altering gut microbiota, reducing neuroinflammation, insulin resistance, and improving synaptic plasticity in mice brain.
Keyphrases
- cognitive impairment
- insulin resistance
- high glucose
- diabetic rats
- resting state
- high fat diet
- randomized controlled trial
- white matter
- cerebral ischemia
- high fat diet induced
- metabolic syndrome
- adipose tissue
- traumatic brain injury
- type diabetes
- functional connectivity
- drug induced
- oxidative stress
- lipopolysaccharide induced
- endothelial cells
- multiple sclerosis
- brain injury