Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer.
Inês de Albuquerque Almeida BatistaLuisa Alejandra HelgueroPublished in: Signal transduction and targeted therapy (2018)
Protein methyltransferases have been shown to methylate histone and non-histone proteins, leading to regulation of several biological processes that control cell homeostasis. Over the past few years, the histone-lysine N-methyltransferase SETD7 (SETD7; also known as SET7/9, KIAA1717, KMT7, SET7, SET9) has emerged as an important regulator of at least 30 non-histone proteins and a potential target for the treatment of several human diseases. This review discusses current knowledge of the structure and subcellular localization of SETD7, as well as its function as a histone and non-histone methyltransferase. This work also underlines the putative contribution of SETD7 to the regulation of gene expression, control of cell proliferation, differentiation and endoplasmic reticulum stress, which indicate that SETD7 is a candidate for novel targeted therapies with the aim of either stimulating or inhibiting its activity, depending on the cell signaling context.
Keyphrases
- dna methylation
- endoplasmic reticulum stress
- gene expression
- cell proliferation
- single cell
- induced apoptosis
- cell therapy
- signaling pathway
- endothelial cells
- squamous cell carcinoma
- amino acid
- risk assessment
- stem cells
- climate change
- oxidative stress
- bone marrow
- protein protein
- binding protein
- young adults
- human health
- mesenchymal stem cells
- pi k akt
- replacement therapy
- pluripotent stem cells
- childhood cancer