IL10RB as a key regulator of COVID-19 host susceptibility and severity.
Georgios VoloudakisGabriel E HoffmanSanan VenkateshKyung Min LeeKristina RehbachJames M VicariWen ZhangNoam D BeckmannShan JiangDaisy A HoaglandJiantao BianLina GaoAndré CorveloKelly ChoJennifer S LeeSudha K IyengarShiuh-Wen LuohSchahram AkbarianRobert StrikerThemistocles L AssimesEric E SchadtMiriam MeradBenjamin R tenOeverAlexander W Charneynull nullnull nullKristen J BrennandJulie A LynchJohn F FullardPanagiotis RoussosPublished in: medRxiv : the preprint server for health sciences (2021)
We establish an integrative data-driven approach for gene target prioritization. We identify and validate IL10RB as a suitable molecular target for modulation of COVID-19 host susceptibility. Finally, we provide evidence for a few readily available medications that would warrant further investigation as drug repositioning candidates.