Two new Scianna variants causing loss of high prevalence antigens: ERMAP model and 3D analysis of the antigens.
Aline FlochChristine Lomas-FrancisSunitha VegeAnna BurgosRoser HoffmanRobin CusickAlexandre G De BrevernConnie M WesthoffPublished in: Transfusion (2022)
We confirm the extracellular location of Scianna residues responsible for antigen expression which predicts direct accessibility to antibodies. Loss of intraprotein interactions appear to be responsible for a Sc null and production of anti-Sc3 with p.117Cys, SC*01 N.03, and for loss of a high prevalence antigen with p.73Cys, termed SCAC for Sc Arg to Cys. Comparative modeling aids our understanding of new alleles and Scianna antigen expression.