Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling.

Ruyi Zhang Shanshan Li Kelly Schippers Yunlong Li Boaz Eimers Marla Lavrijsen Ling Wang Guofei Cui Xin Chen Maikel Petrus Peppelenbosch Joyce H G Lebbink Ron Smits

Published in: Cancer research (2024)

Characterization of 80 tumor-associated missense variants of AXIN1 reveals a subset of 18 mutations that disrupt its β-catenin regulatory function, whereas the majority are passenger mutations.

Keyphrases

copy number
epithelial mesenchymal transition
transcription factor
genome wide
cell proliferation
gene expression
dna methylation