Xin Chen

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 50

Top Venues

Cell death & disease

Hepatology (Baltimore, Md.)

Hepatology communications

Cancer research

university of california

University of California, San Francisco (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

university of california Jan 01 2003

United States

Professor :: Department of Bioengineering and Therapeutic Sciences

Education History

University of California, San Francisco Jan 01 2003

United States

PHD :: Department of Bioengineering and Therapeutic Sciences

Publications

Ruyi Zhang, Shanshan Li, Kelly Schippers, Yunlong Li, Boaz Eimers, Marla Lavrijsen, Ling Wang, Guofei Cui, Xin Chen, Maikel Petrus Peppelenbosch, Joyce H G Lebbink, Ron Smits
Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling. Cancer research (2024)
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F Calvisi, Benjamin L Green, Xin Chen
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. Cell death & disease 15 (6) (2024)
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F Calvisi, Benjamin L Green, Xin Chen
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. Cell death & disease 15 (6) (2024)
Ruyi Zhang, Shanshan Li, Kelly Schippers, Yunlong Li, Boaz Eimers, Marla Lavrijsen, Ling Wang, Guofei Cui, Xin Chen, Maikel Petrus Peppelenbosch, Joyce H G Lebbink, Ron Smits
Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling. Cancer research 84 (9) (2024)
Diyala Shihadih, Xue Wang, Peter-James H Zushin, Pavlo V Khodakivskyi, Hyo Min Park, Emily Tso, Jena Shiblak, Angela Misic, Sharon M Louie, Catherine P Ward, Marc K Hellerstein, Daniel K Nomura, Elena Goun, Francesco Urigo, Diego F Calvisi, Xin Chen, Andreas Stahl
FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma. Molecular cancer research : MCR 22 (6) (2024)
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F Calvisi, Benjamin L Green, Xin Chen
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. Cell death & disease 15 (6) (2024)
Ruyi Zhang, Shanshan Li, Kelly Schippers, Yunlong Li, Boaz Eimers, Marla Lavrijsen, Ling Wang, Guofei Cui, Xin Chen, Maikel Petrus Peppelenbosch, Joyce H G Lebbink, Ron Smits
Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling. Cancer research 84 (9) (2024)
Diyala Shihadih, Xue Wang, Peter-James H Zushin, Pavlo V Khodakivskyi, Hyo Min Park, Emily Tso, Jena Shiblak, Angela Misic, Sharon M Louie, Catherine P Ward, Marc K Hellerstein, Daniel K Nomura, Elena Goun, Francesco Urigo, Diego F Calvisi, Xin Chen, Andreas Stahl
FATP5 is indispensable for the growth of intrahepatic cholangiocarcinoma. Molecular cancer research : MCR (2024)
Wennan Zhao, Xue Wang, Lifeng Han, Chunze Zhang, Chenxi Wang, Dexin Kong, Mingzhe Zhang, Tong Xu, Gen Li, Ge Hu, Jiahua Luo, Sook Wah Yee, Jia Yang, Andreas Stahl, Xin Chen, Youcai Zhang
SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis. Nature communications 15 (1) (2024)
Ruyi Zhang, Shanshan Li, Kelly Schippers, Yunlong Li, Boaz Eimers, Marla Lavrijsen, Ling Wang, Guofei Cui, Xin Chen, Maikel Petrus Peppelenbosch, Joyce H G Lebbink, Ron Smits
Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling. Cancer research 84 (9) (2024)
Diyala Shihadih, Xue Wang, Peter-James H Zushin, Pavlo V Khodakivskyi, Hyo Min Park, Emily Tso, Jena Shiblak, Angela Misic, Sharon M Louie, Catherine P Ward, Marc K Hellerstein, Daniel K Nomura, Elena Goun, Francesco Urigo, Diego F Calvisi, Xin Chen, Andreas Stahl
FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma. Molecular cancer research : MCR 22 (6) (2024)
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F Calvisi, Benjamin L Green, Xin Chen
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. Cell death & disease 15 (6) (2024)
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F Calvisi, Benjamin L Green, Xin Chen
Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma. Cell death & disease 15 (6) (2024)
Ruyi Zhang, Shanshan Li, Kelly Schippers, Yunlong Li, Boaz Eimers, Marla Lavrijsen, Ling Wang, Guofei Cui, Xin Chen, Maikel Petrus Peppelenbosch, Joyce H G Lebbink, Ron Smits
Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling. Cancer research 84 (9) (2024)
Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang
Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis. Cell death & disease 14 (7) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage. Hepatology communications 7 (3) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage. Hepatology communications 7 (3) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage. Hepatology communications 7 (3) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage. Hepatology communications 7 (3) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
A new mission for an old anti-cancer drug: harnessing hepatocyte-specific metabolic pathways against liver tumors. Signal transduction and targeted therapy 8 (1) (2023)
Weiting Liao, Diego F Calvisi, Xin Chen
Year in review: Liver cancer research in 2022: tumor microenvironment takes the central stage. Hepatology communications 7 (3) (2023)
Haichuan Wang, Yi Zhou, Hongwei Xu, Xue Wang, Yi Zhang, Runze Shang, Marie O'Farrell, Stephanie Roessler, Carsten Sticht, Andreas Stahl, Matthias Evert, Diego F Calvisi, Yong Zeng, Xin Chen
Therapeutic efficacy of FASN inhibition in preclinical models of HCC. Hepatology (Baltimore, Md.) 76 (4) (2022)
Haichuan Wang, Xin Chen
Hydrodynamic Injection for Developing NASH Model. Methods in molecular biology (Clifton, N.J.) 2455 (2022)
Binyong Liang, Haichuan Wang, Yu Qiao, Xue Wang, Manning Qian, Xinhua Song, Yi Zhou, Yi Zhang, Runze Shang, Li Che, Yifa Chen, Zhiyong Huang, Hong Wu, Satdarshan Paul Monga, Yong Zeng, Diego F Calvisi, Xiaoping Chen, Xin Chen
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation-driven hepatocarcinogenesis. Hepatology (Baltimore, Md.) (2022)
Arianna Pocaterra, Gloria Scattolin, Patrizia Romani, Cindy Ament, Silvia Ribback, Xin Chen, Matthias Evert, Diego F Calvisi, Sirio Dupont
Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development. Communications biology 4 (1) (2021)
Fan Yao, Yalan Deng, Yang Zhao, Ying Mei, Yilei Zhang, Xiaoguang Liu, Consuelo Martinez, Xiaohua Su, Roberto R Rosato, Hongqi Teng, Qinglei Hang, Shannon Yap, Dahu Chen, Yumeng Wang, Mei-Ju May Chen, Mutian Zhang, Han Liang, Dong Xie, Xin Chen, Hao Zhu, Jenny C Chang, M James You, Yutong Sun, Boyi Gan, Li Ma
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nature communications 12 (1) (2021)
Taylor Gill, Haichuan Wang, Raj Bandaru, Matthew A Lawlor, Chenyue Lu, Linda T Nieman, Junyan Tao, Yixian Zhang, Daniel G Anderson, David Tsai Ting, Xin Chen, James E Bradner, Christopher J Ott
Selective targeting of MYC mRNA by stabilized antisense oligonucleotides. Oncogene 40 (47) (2021)
Junyan Tao, Yekaterina Krutsenko, Akshata Moghe, Sucha Singh, Minakshi Poddar, Aaron Bell, Michael Oertel, Aatur D Singhi, David Geller, Xin Chen, Amaia Lujambio, Silvia Liu, Satdarshan Paul Monga
Nuclear factor erythroid 2-related factor 2 and β-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications. Hepatology (Baltimore, Md.) 74 (2) (2021)
Haichuan Wang, Pan Wang, Meng Xu, Xinhua Song, Hong Wu, Matthias Evert, Diego F Calvisi, Yong Zeng, Xin Chen
Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression. Cell death & disease 12 (2) (2021)
Haichuan Wang, Xin Chen, Diego F Calvisi
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics. Expert opinion on therapeutic targets 25 (8) (2021)
Hongwei Xu, Kefei Chen, Runze Shang, Xinyan Chen, Yi Zhang, Xinhua Song, Matthias Evert, Sheng Zhong, Bo Li, Diego F Calvisi, Xin Chen
Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma. Cell death & disease 12 (10) (2021)
Haichuan Wang, Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che, Jie Zhang, Yi Zhou, Antonio Cigliano, Cindy Ament, Daphne Superville, Silvia Ribback, Melissa Reeves, Giovanni M Pes, Binyong Liang, Hong Wu, Matthias Evert, Diego F Calvisi, Yong Zeng, Xin Chen
Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans. Hepatology (Baltimore, Md.) 74 (1) (2021)
Bin Chen, Lana Garmire, Diego F Calvisi, Mei-Sze Chua, Robin K Kelley, Xin Chen
Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma. Nature reviews. Gastroenterology & hepatology 17 (4) (2020)
Xinyan Chen, Andras Kiss, Zsuzsa Schaff, Katja Evert, Yi Zhang, Sheng Zhong, Jingxiao Wang, Matthias Evert, Diego F Calvisi, Xin Chen
CDK9 is dispensable for YAP-driven hepatoblastoma development. Pediatric blood & cancer 67 (5) (2020)
Serena Mancarella, Grazia Serino, Francesco Dituri, Antonio Cigliano, Silvia Ribback, Jingxiao Wang, Xin Chen, Diego F Calvisi, Gianluigi Giannelli
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis. Cell death and differentiation 27 (8) (2020)
Runze Shang, Xinhua Song, Pan Wang, Yi Zhou, Xinjun Lu, Jingxiao Wang, Meng Xu, Xinyan Chen, Kirsten Utpatel, Li Che, Binyong Liang, Antonio Cigliano, Matthias Evert, Diego F Calvisi, Xin Chen
Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma. Gut 70 (9) (2020)
Bin Chen, Lana Garmire, Diego F Calvisi, Mei-Sze Chua, Robin K Kelley, Xin Chen
Publisher Correction: Harnessing big 'omics' data and AI for drug discovery in hepatocellular carcinoma. Nature reviews. Gastroenterology & hepatology (2020)
Xinjun Lu, Panagiotis Paliogiannis, Diego F Calvisi, Xin Chen
Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies. Hepatology (Baltimore, Md.) (2020)
Pan Wang, Xinhua Song, Dan Cao, Kairong Cui, Jingxiao Wang, Kirsten Utpatel, Runze Shang, Haichuan Wang, Li Che, Matthias Evert, Keji Zhao, Diego F Calvisi, Xin Chen
Oncogene-dependent function of BRG1 in hepatocarcinogenesis. Cell death & disease 11 (2) (2020)
Xin Chen, Satdarshan P Monga, Diego F Calvisi
Reply. Hepatology (Baltimore, Md.) 70 (2) (2020)
Tatsuo Kido, Z Laura Tabatabai, Xin Chen, Yun-Fai Chris Lau
Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis. Cancer science 111 (8) (2020)
Jiaoyuan Jia, Li Che, Antonio Cigliano, Xue Wang, Graziella Peitta, Junyan Tao, Sheng Zhong, Silvia Ribback, Matthias Evert, Xin Chen, Diego F Calvisi
Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis. International journal of molecular sciences 21 (22) (2020)
Pan Wang, Xinhua Song, Kirsten Utpatel, Runze Shang, Yoon Mee Yang, Meng Xu, Jie Zhang, Li Che, John D Gordan, Antonio Cigliano, Ekihiro Seki, Matthias Evert, Diego F Calvisi, Xiaosong Hu, Xin Chen
MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell death & disease 10 (2) (2019)
Yu Qiao, Jingxiao Wang, Eylul Karagoz, Binyong Liang, Xinhua Song, Runze Shang, Katja Evert, Meng Xu, Li Che, Matthias Evert, Diego F Calvisi, Junyan Tao, Bruce Wang, Satdarshan P Monga, Xin Chen
Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice. Hepatology (Baltimore, Md.) 70 (6) (2019)
Li Che, Wenna Chi, Yu Qiao, Jie Zhang, Xinhua Song, Ye Liu, Lei Li, Jiaoyuan Jia, Maria G Pilo, Jingxiao Wang, Antonio Cigliano, Zhilong Ma, Wenhua Kuang, Zefang Tang, Zemin Zhang, Guanghou Shui, Silvia Ribback, Frank Dombrowski, Matthias Evert, Rosa Maria Pascale, Carla Cossu, Giovanni Mario Pes, Timothy F Osborne, Diego F Calvisi, Xin Chen, Ligong Chen
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut 69 (1) (2019)
Zhong Xu, Meng Xu, Pin Liu, Shu Zhang, Runze Shang, Yu Qiao, Li Che, Silvia Ribback, Antonio Cigliano, Katja Evert, Rosa M Pascale, Frank Dombrowski, Matthias Evert, Xi Chen, Diego F Calvisi, Xin Chen
The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans. Hepatology (Baltimore, Md.) 70 (5) (2019)
Xianqiong Liu, Junjie Hu, Xinhua Song, Kirsten Utpatel, Yi Zhang, Pan Wang, Xinjun Lu, Jie Zhang, Meng Xu, Tao Su, Li Che, Jingxiao Wang, Matthias Evert, Diego F Calvisi, Xin Chen
Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. Cancers 11 (7) (2019)
Xianqiong Liu, Xinhua Song, Jie Zhang, Zhong Xu, Li Che, Yu Qiao, Yunuen Ortiz Pedraza, Antonio Cigliano, Rosa M Pascale, Diego F Calvisi, Yanju Liu, Xin Chen
Focal adhesion kinase activation limits efficacy of Dasatinib in c-Myc driven hepatocellular carcinoma. Cancer medicine 7 (12) (2018)
Jingxiao Wang, Mingjie Dong, Zhong Xu, Xinhua Song, Shanshan Zhang, Yu Qiao, Li Che, John Gordan, Kaiwen Hu, Yan Liu, Diego F Calvisi, Xin Chen
Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene 37 (24) (2018)
Jiaoyuan Jia, Yu Qiao, Maria G Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Shao, Diego F Calvisi, Xin Chen
Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. PloS one 12 (9) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Xin Chen