Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging.
Samantha J MillsD du PlessisPiyali PalG ThompsonG BuonacorrsiC SohGeoffrey J M ParkerAlan JacksonPublished in: AJNR. American journal of neuroradiology (2015)
A correlation between the estimate of volume of the extravascular extracellular space and mitotic activity is reported. Further work is warranted to establish how dynamic contrast-enhanced MRI parameters relate to more quantitative histologic measurements, including markers of proliferation and measures of vascular endothelial growth factor expression.