Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.
Faye A H CoolesJessica R TarnDennis William LendremNajib NaamaneChung Ma LinBen MillarNicola J ManeyAmy E AndersonNishanthi ThalayasingamJulie DibollVincent BondetDarragh DuffyMichael R BarnesGraham R SmithSandra NgDavid WatsonRafael HenkinAndrew P CopeLouise N ReynardArthur G Prattnull nullJohn Dudley IsaacsPublished in: Annals of the rheumatic diseases (2022)
Our data suggest that, in eRA, IFN-α can cause a sustained, epigenetically mediated, pathogenic increase in lymphocyte activation and proliferation, and that the IGS is, therefore, a robust prognostic biomarker. Its persistent harmful effects provide a rationale for the initial therapeutic targeting of IFN-α in selected patients with eRA.