A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model.
Md Nasrul HodaSusan C FaganMohammad B KhanKumar VaibhavAizaz ChaudharyPhillip WangKrishnan M DhandapaniJennifer L WallerDavid C HessPublished in: Experimental & translational stroke medicine (2014)
In the future, combining these two safe and low cost interventions in the ambulance has the potential to "freeze" the penumbra and improve outcomes in stroke patients. This pre-clinical 2 × 2 design can be easily translated into a pre-hospital clinical trial.