Early epigenetic changes of Alzheimer's disease in the human hippocampus.
Idoia Blanco-LuquinBlanca Acha SantamariaAmaya Urdánoz-CasadoJavier Sánchez-Ruiz De GordoaJanire Vicuña-UrrizaMiren RoldánAlberto LabargaMaría Victoria ZelayaCarolina CabelloIván Méndez-LópezMaite MendiorozPublished in: Epigenetics (2020)
AD: Alzheimer's disease; DMPs: Differentially methylated positions; CSF: Cerebrospinal fluid; βA42: β-amyloid 42; PET: positron emission tomography; 5mC: 5-methyl cytosine; CpG: cytosine-guanine dinucleotides; ANK1: ankyrin-1; BIN1: amphiphysin II; p-tau: hyperphosphorylated tau; CERAD: Consortium to Establish A Registry for Alzheimer's Disease; SD: standard deviation; ANOVA: one-way analysis of variance; VLCFAs: very long-chain fatty acids; DHA: docosahexaenoic acid; mTOR: mechanistic target of rapamycin.