L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.
Jing HuangXiaobo WangBing LiShiyu ShenRuina WangHongru TaoJunchi HuJin YuHualiang JiangKaixian ChenCheng LuoYongjun DangYuanyuan ZhangPublished in: Journal for immunotherapy of cancer (2022)
Our study illustrated L-5-HTP's inhibitory effect on PD-L1 induction stimulated by IFN-γ in tumor cells and also provided insight into repurposing L-5-HTP for use in tumor immunotherapy.