Integration of dietary nutrition and TRIB3 action into diabetes mellitus.
Guangping LuJiahao LiTing GaoQingbo LiuOu ChenXiaohui ZhangMengjie XiaoYuanfang GuoJie WangYufeng TangJunlian GuPublished in: Nutrition reviews (2023)
Despite intensive studies for decades, the common mechanistic correlations among the underlying pathology of diabetes mellitus (DM), its complications, and effective clinical treatments remain poorly characterized. High-quality diets and nutrition therapy have played an indispensable role in the management of DM. More importantly, tribbles homolog 3 (TRIB3), a nutrient-sensing and glucose-responsive regulator, might be an important stress-regulatory switch, linking glucose homeostasis and insulin resistance. Therefore, this review aimed to introduce the latest research progress on the crosstalk between dietary nutrition intervention and TRIB3 in the development and treatment of DM. This study also summarized the possible mechanisms involved in the signaling pathways of TRIB3 action in DM, in order to gain an in-depth understanding of dietary nutrition intervention and TRIB3 in the pathogenesis of DM at the organism level.
Keyphrases
- glycemic control
- physical activity
- blood glucose
- insulin resistance
- randomized controlled trial
- type diabetes
- transcription factor
- adipose tissue
- signaling pathway
- cancer therapy
- high fat diet
- polycystic ovary syndrome
- drug delivery
- epithelial mesenchymal transition
- metabolic syndrome
- combination therapy
- stress induced
- skeletal muscle
- smoking cessation
- high fat diet induced