Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation.

Yu-Ting TsaiWei-Lun LoPin-Yuan ChenChiung-Yuan KoJian-Ying ChuangTzu-Jen KaoWen-Bing YangKwang-Yu ChangChia-Yang HungUshio KikkawaWen-Chang ChangTsung-I Hsu

Published in: Journal of biomedical science (2022)

Sp1-regulated PGE2 production activates FAO and TCA cycle in mitochondria, through EP1 and EP3 receptors, resulting in TMZ resistance in GBM. These results will provide us a new strategy to attenuate drug resistance or to re-sensitize recurred GBM.

Keyphrases

fatty acid
oxidative stress
cell death
transcription factor
hydrogen peroxide
reactive oxygen species