Identification of Key Genes and Potential Mechanisms Based on the Autophagy Regulatory Network in Osteoclasts Using a Murine Osteoarthritis Model.

Weicheng ZhangHouyi SunWei ZhangYaozeng XuDechun Geng

Published in: Journal of inflammation research (2022)

Our results reveal that the role of autophagy in osteoclasts could be a regulatory mechanism in OA and that these autophagy-related genes might be targets for the intervention of OA disease.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
knee osteoarthritis
genome wide
randomized controlled trial
transcription factor
rheumatoid arthritis
bioinformatics analysis
risk assessment
climate change
human health