Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice.
Pauline JanssenL De PauwM MambrettiOlaya LaraJ WalckiersL MackensIlse RoomanB GuillaumeMark De RidderGamze AtesAnn MassiePublished in: International journal of radiation biology (2023)
Overall health of the mice did not seem to be majorly impacted by TBI followed by BMT during adulthood. Yet, TBI-induced alterations in the brain and behavior could lead to erroneous conclusions on the function of a protein on immune cells when comparing mouse chimeras with different genetic backgrounds that might display altered susceptibility to radiation-induced damage. Ultimately, the BMT model we here present could also be used to study the related long-term consequences of TBI and BMT seen in patients.
Keyphrases
- radiation induced
- traumatic brain injury
- bone marrow
- end stage renal disease
- severe traumatic brain injury
- resting state
- white matter
- public health
- radiation therapy
- ejection fraction
- newly diagnosed
- mild traumatic brain injury
- healthcare
- chronic kidney disease
- high fat diet induced
- mesenchymal stem cells
- prognostic factors
- peritoneal dialysis
- mental health
- high glucose
- functional connectivity
- depressive symptoms
- gene expression
- oxidative stress
- drug induced
- diabetic rats
- risk assessment
- cell therapy
- genome wide
- climate change
- type diabetes
- wild type
- human health
- early life
- small molecule
- protein protein
- social media
- stress induced