Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability.
Christopher Mark LaCoursiereJeremy F P UllmannHyun Yong KohLaura TurnerCristina M BakerBarbara RobensWanqing ShaoAlexander RotenbergChristopher Michael McGrawAnnapurna H PoduriPublished in: bioRxiv : the preprint server for biology (2024)
mutant larvae have fewer inhibitory interneurons than wild type in the optic tectum. CRISPR-generated mutants of epilepsy genes displayed convergent transcriptional dysregulation, consistent with developmental abnormalities and their hyperexcitability phenotype.
Keyphrases
- wild type
- genome wide
- endothelial cells
- dna methylation
- bioinformatics analysis
- genome wide identification
- gene expression
- transcription factor
- induced pluripotent stem cells
- optical coherence tomography
- genome editing
- aedes aegypti
- oxidative stress
- drosophila melanogaster
- heat stress
- heat shock
- zika virus
- heat shock protein