Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma.
Waseem LoneAlyssa BouskaSunandini SharmaCatalina AmadorSaumyaranjan MallickTyler A HerekTayla B HeavicanJiayu YuSoon Thye LimChoon-Kiat OngGraham W SlackKerry J SavageAndreas RosenwaldGerman OttJames R CookAndrew L FeldmanLisa M RimszaTimothy W McKeithanTimothy C GreinerDennis D WeisenburgerFederica MelleGiovanna MottaStefano PileriJulie M VoseWing C ChanJaveed IqbalPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Unique miRNAs and deregulated oncogenic pathways are associated with PTCL subtypes. Upregulated miRNA-126-3p and miR-145-5p expression regulate RhoA-GTPase and inhibit T-cell migration, crucial for AITL pathobiology.