Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?
Megan M Garcia-CurranElizabeth HaddadKatelin P PattersonMankin ChoyCeline M DubéTallie Z BaramAndré ObenausPublished in: Epilepsia (2018)
Early T2 WI MRI changes after eFSE provide a strong predictive measure of epileptogenesis following eFSE, on both high-field and clinical MRI scanners. Importantly, the extension of the acute signal changes to at least 6 hours after the FSE enables its inclusion in clinical studies. Chronic elevations of T2 relaxation times within the hippocampal formation and related structures are common to human and rodent FSE, suggesting that similar processes are involved across species.
Keyphrases
- magnetic resonance imaging
- contrast enhanced
- diffusion weighted imaging
- temporal lobe epilepsy
- endothelial cells
- computed tomography
- liver failure
- drug induced
- magnetic resonance
- primary care
- high resolution
- respiratory failure
- aortic dissection
- single molecule
- intensive care unit
- pluripotent stem cells
- urinary tract infection
- acute respiratory distress syndrome
- brain injury
- extracorporeal membrane oxygenation
- blood brain barrier
- subarachnoid hemorrhage