Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine.
Bethany D HarrisSrilalitha KurugantiAshlesha DeshpandePaul A GoepfertW Winn ChathamMark R WalterPublished in: Lupus (2020)
The measurement of autoantibodies to multiple interferon subtypes in serum and urine may provide an alternative method for following interferon-mediated systemic lupus erythematosus disease activity. The results suggest autoantibodies might be used for patient monitoring and/or identifying additional cytokine signaling pathways that are functioning in different systemic lupus erythematosus patients.
Keyphrases
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis patients
- dendritic cells
- ankylosing spondylitis
- end stage renal disease
- newly diagnosed
- juvenile idiopathic arthritis
- signaling pathway
- rheumatoid arthritis
- prognostic factors
- peritoneal dialysis
- immune response
- case report
- cell proliferation
- oxidative stress
- patient reported
- pi k akt
- induced apoptosis