Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis.

Jasmohan Singh BajajGenta KakiyamaDerrick ZhaoHajime TakeiAndrew FaganPhillip HylemonHuiping ZhouWilliam M PandakHiroshi NittonoOliver FiehnNita SalzmanMary HoltzPippa SimpsonEdith A GavisDouglas M HeumanRunping LiuDae Joong KangMasoumeh SikaroodiPatrick M Gillevet

Published in: Alcoholism, clinical and experimental research (2017)

Despite cirrhosis, continued alcohol misuse predisposes patients to widespread dysbiosis with alterations in microbial functionality such as a toxic BA profile, which can lead to intestinal and systemic inflammation.

Keyphrases

end stage renal disease
chronic pain
ejection fraction
endothelial cells
newly diagnosed
chronic kidney disease
microbial community
peritoneal dialysis
prognostic factors
pluripotent stem cells