Establishing the safety of selective digestive decontamination within the ICU population: a bridge too far?
James C HurleyPublished in: Trials (2023)
The basis for the mortality difference between control and intervention groups of SDD studies remains unclear. Several paradoxical results are consistent with a spillover effect that would conflate the inference of benefit originating from RCCTs. Moreover, this spillover effect would constitute to herd peril.