Environmentally Friendly Protocol for 2,3-Difunctionlization of Indole Derivatives.
Wen-Wu SunNa ChenTing-Ting WeiGuo-Jing YouHao YangJi-Kai LiuBin WuPublished in: The Journal of organic chemistry (2020)
Environmentally friendly and highly regioselective C-3 dichlorination and C-2 oxidation of N-substituted indoles have been established using NaCl as a chlorine source and H2O as an oxygen source. A series of 3,3-dichloro-2-oxindoles were obtained in moderate to excellent yields. The gram-scale synthesis and derivatization reaction were explored. The possible mechanism for this reaction was elucidated.
Keyphrases
- electron transfer
- low cost
- randomized controlled trial
- ms ms
- gram negative
- drinking water
- molecular docking
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- high intensity
- gas chromatography mass spectrometry
- simultaneous determination
- gas chromatography
- mass spectrometry
- tandem mass spectrometry
- multidrug resistant
- nitric oxide