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Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors.

Clint A StalneckerKajal R GroverA Cole EdwardsMichael Francis ColemanRunying YangJonathan M DeLibertyBjoern PapkeCraig M GoodwinMariaelena PierobonEmanuel F PetricoinPrson GautamKrister WennerbergAdrienne D CoxChanning J DerStephen D HurstingKirsten L Bryant
Published in: Cancer research (2022)
Compensatory upregulation of IGF1R and ERK-MAPK signaling limits the efficacy of autophagy inhibitors chloroquine and hydroxychloroquine, and their concurrent inhibition synergistically increases autophagy dependence and chloroquine sensitivity in pancreatic ductal adenocarcinoma.
Keyphrases
  • signaling pathway
  • pi k akt
  • cell death
  • endoplasmic reticulum stress
  • oxidative stress
  • cell proliferation
  • locally advanced
  • binding protein
  • squamous cell carcinoma
  • poor prognosis
  • growth hormone