Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors.
Clint A StalneckerKajal R GroverA Cole EdwardsMichael Francis ColemanRunying YangJonathan M DeLibertyBjoern PapkeCraig M GoodwinMariaelena PierobonEmanuel F PetricoinPrson GautamKrister WennerbergAdrienne D CoxChanning J DerStephen D HurstingKirsten L BryantPublished in: Cancer research (2022)
Compensatory upregulation of IGF1R and ERK-MAPK signaling limits the efficacy of autophagy inhibitors chloroquine and hydroxychloroquine, and their concurrent inhibition synergistically increases autophagy dependence and chloroquine sensitivity in pancreatic ductal adenocarcinoma.