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Long-term inter-platform reproducibility, bias, and linearity of commercial PDFF MRI methods for fat quantification: a multi-center, multi-vendor phantom study.

Erika SchneiderErick M RemerNancy A ObuchowskiCharles A McKenzieXiaobo DingSankar D Navaneethan
Published in: European radiology (2021)
• Phantom fat fraction (PDFF) MRI measurements over 35 months demonstrated good linearity, accuracy, and reproducibility for the vendor systems investigated. • Non-linear effects were negligible (linear slope of 0.94) over 0-100% fat; however, significant vendor (p < 0.001) and field strength (p<0.001) differences in bias and longitudinal variability were identified. Bias ranged from 2.4 to - 3.8% for 0-100 weight% fat, respectively. • Measurement bias could affect the accuracy of PDFF in clinical use. As the reproducibility coefficient was 6.93%, only greater changes in % fat can be considered true differences when making longitudinal PDFF measurements on different MR systems.
Keyphrases
  • adipose tissue
  • contrast enhanced
  • fatty acid
  • magnetic resonance imaging
  • diffusion weighted imaging
  • body mass index
  • physical activity
  • magnetic resonance
  • computed tomography
  • weight loss
  • image quality
  • dual energy