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The immunoregulatory role of p21 in the development of the temporomandibular joint-osteoarthritis.

Tsendsuren Khurel-OchirTakashi IzawaAkihiko IwasaFumiya KanoAkihito YamamotoEiji Tanaka
Published in: Clinical and experimental dental research (2021)
Our findings indicate that p21 in chondrocytes contributes to regulate matrix synthesis via the control ofm aggrecan and MMP-13 expression under mechanical stress. Thus, p21 might regulate the pathogenesis of osteoarthritis in the TMJ.
Keyphrases
  • rheumatoid arthritis
  • knee osteoarthritis
  • poor prognosis
  • binding protein
  • cell migration
  • stress induced