The immunoregulatory role of p21 in the development of the temporomandibular joint-osteoarthritis.
Tsendsuren Khurel-OchirTakashi IzawaAkihiko IwasaFumiya KanoAkihito YamamotoEiji TanakaPublished in: Clinical and experimental dental research (2021)
Our findings indicate that p21 in chondrocytes contributes to regulate matrix synthesis via the control ofm aggrecan and MMP-13 expression under mechanical stress. Thus, p21 might regulate the pathogenesis of osteoarthritis in the TMJ.