PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models.
Ki-Cheong ParkJung Min KimSang Yong KimSeok-Mo KimJin Hong LimMin Ki KimSungsoon FangYonjung KimGordon B MillsSung Hoon NohJae-Ho CheongPublished in: BMC medicine (2023)
Our results suggest that PGC1α is a key regulator of anti-apoptosis in metabolic and genotoxic stress-resistant cells, inducing PMCA expression and allowing survival in glucose-deprived conditions. We have discovered a novel therapeutic target candidate that could be employed for the treatment of patients with refractory cancers.
Keyphrases
- cell cycle arrest
- induced apoptosis
- endoplasmic reticulum stress
- cell death
- poor prognosis
- oxidative stress
- papillary thyroid
- pi k akt
- transcription factor
- squamous cell
- blood glucose
- childhood cancer
- free survival
- type diabetes
- metabolic syndrome
- binding protein
- long non coding rna
- lymph node metastasis
- insulin resistance
- replacement therapy