Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease.

Jiansong FangPengyue ZhangQuan WangChien-Wei ChiangYadi ZhouYuan HouJielin XuRui ChenBin ZhangStephen J LewisJames B LeverenzAndrew A PieperBingshan LiLang LiJeffrey CummingsFeixiong Cheng

Published in: Alzheimer's research & therapy (2022)

In summary, we present an integrated, network-based artificial intelligence methodology to rapidly translate GWAS findings and multi-omics data to genotype-informed therapeutic discovery in AD.

Keyphrases

artificial intelligence
big data
machine learning
deep learning
small molecule
genome wide
electronic health record
cognitive decline
high throughput
adverse drug
gene expression
emergency department
data analysis
mild cognitive impairment