Feixiong Cheng

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 47

Top Venues

Nature communications

PLoS computational biology

NPJ digital medicine

Alzheimer's research & therapy

Case Western Reserve University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Case Western Reserve University

United States

Faculty Member :: Case Comprehensive Cancer Center

Cleveland Clinic Jul 02 2018

United States

Assistant Professor :: Genome Medicine Institute

Northeastern University

United States

Research Fellow

Vanderbilt University Medical Center

United States

Research Fellow

Publications

Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew B Brendel, Jacqueline R M A Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C Cincotta, Xinghua Shi, Claire Henchcliffe, James B Leverenz, Jeffrey Cummings, Michael S Okun, Jiang Bian, Feixiong Cheng, Fei Wang
Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data. NPJ digital medicine 7 (1) (2024)
Tingting Li, Xuanbai Ren, Xiaoli Luo, Zhuole Wang, Zhenlu Li, Xiaoyan Luo, Jun Shen, Yun Li, Dan Yuan, Ruth Nussinov, Xiangxiang Zeng, Junfeng Shi, Feixiong Cheng
A Foundation Model Identifies Broad-Spectrum Antimicrobial Peptides against Drug-Resistant Bacterial Infection. Nature communications 15 (1) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Feixiong Cheng, Yayan Feng, Margaret Flanagan, Borna Bonakdarpour, Pouya Jamshidi, Rudolph Castellani, Qinwen Mao, Xiaona Chu, Hongyu Gao, Yunlong Liu, Jielin Xu, Yuan Hou, William R Martin, Peter Nelson, James Leverenz, Andrew Pieper, Jeffrey L Cummings
Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia. Research square (2024)
Yayan Feng, Margaret E Flanagan, Borna Bonakdarpour, Pouya Jamshidi, Rudolph J Castellani, Qinwen Mao, Xiaona Chu, Hongyu Gao, Yunlong Liu, Jielin Xu, Yuan Hou, William R Martin, Peter T Nelson, James B Leverenz, Andrew A Pieper, Jeffrey L Cummings, Feixiong Cheng
Single-nucleus multiome analysis of human cerebellum in Alzheimer's disease-related dementia. Research square (2024)
Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew B Brendel, Jacqueline R M A Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C Cincotta, Xinghua Shi, Claire Henchcliffe, James B Leverenz, Jeffrey Cummings, Michael S Okun, Jiang Bian, Feixiong Cheng, Fei Wang
Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data. NPJ digital medicine 7 (1) (2024)
Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew B Brendel, Jacqueline R M A Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C Cincotta, Xinghua Shi, Claire Henchcliffe, James B Leverenz, Jeffrey Cummings, Michael S Okun, Jiang Bian, Feixiong Cheng, Fei Wang
Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data. NPJ digital medicine 7 (1) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Pengyue Zhang, Yuan Hou, Chien-Wei Chiang, Andrew A Pieper, Jeffrey Cummings, Feixiong Cheng
Reply to: Comparator choices in pharmacoepidemiology studies of Alzheimer's disease. Nature aging (2023)
Jiansong Fang, Pengyue Zhang, Yadi Zhou, Chien-Wei Chiang, Juan Tan, Yuan Hou, Shaun Stauffer, Lang Li, Andrew A Pieper, Jeffrey Cummings, Feixiong Cheng
Author Correction: Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease. Nature aging (2023)
Dionysios C Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R Lunavat, Daniel J Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi M Deshpande, Joris Guyon, Yadi Zhou, Capucine R Magaut, Juliana Seder, Laura Neises, Sarah E Williford, Johannes Meiser, Andrew J Scott, Peter Sajjakulnukit, Jason A Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas Andreas Lyssiotis, Daniel R Wahl, Anita B Hjelmeland, Jubayer A Hossain, Hrvoje Miletic, Justin D Lathia
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nature cancer (2023)
Chengxi Zang, Hao Zhang, Jie Xu, Hansi Zhang, Sajjad Fouladvand, Shreyas Havaldar, Feixiong Cheng, Kun Chen, Yong Chen, Benjamin Scott Glicksberg, Jin Chen, Jiang Bian, Fei Wang
High-throughput target trial emulation for Alzheimer's disease drug repurposing with real-world data. Nature communications 14 (1) (2023)
Dionysios C Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R Lunavat, Daniel J Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi M Deshpande, Joris Guyon, Yadi Zhou, Capucine R Magaut, Juliana Seder, Laura Neises, Sarah E Williford, Johannes Meiser, Andrew J Scott, Peter Sajjakulnukit, Jason A Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas Andreas Lyssiotis, Daniel R Wahl, Anita B Hjelmeland, Jubayer A Hossain, Hrvoje Miletic, Justin D Lathia
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. Nature cancer (2023)
Grace E Weber, Maria E Khrestian, Elizabeth D Tuason, Yvonne Shao, Jagan A Pillai, Stephen M Rao, Hao Feng, Yadi Zhou, Feixiong Cheng, Tara M DeSilva, Shaun R Stauffer, James B Leverenz, Lynn M Bekris
Peripheral sTREM2-Related Inflammatory Activity Alterations in Early-Stage Alzheimer's Disease. Journal of immunology (Baltimore, Md. : 1950) 208 (10) (2022)
Yuan Hou, Yadi Zhou, Lara Jehi, Yuan Luo, Michaela U Gack, Timothy A Chan, Haiyuan Yu, Charis Eng, Andrew A Pieper, Feixiong Cheng
Aging-related cell type-specific pathophysiologic immune responses that exacerbate disease severity in aged COVID-19 patients. Aging cell 21 (2) (2022)
Jiansong Fang, Pengyue Zhang, Quan Wang, Chien-Wei Chiang, Yadi Zhou, Yuan Hou, Jielin Xu, Rui Chen, Bin Zhang, Stephen J Lewis, James B Leverenz, Andrew A Pieper, Bingshan Li, Lang Li, Jeffrey Cummings, Feixiong Cheng
Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer's disease. Alzheimer's research & therapy 14 (1) (2022)
Xiangxiang Zeng, Hongxin Xiang, Linhui Yu, Jianmin Wang, Kenli Li, Ruth Nussinov, Feixiong Cheng
Accurate prediction of molecular targets using a self-supervised image representation learning framework. Research square (2022)
Marina Bykova, Yuan Hou, Charis Eng, Feixiong Cheng
Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes. Human molecular genetics 31 (R1) (2022)
Jennifer E Dawson, Iris Nira Smith, William Martin, Krishnendu Khan, Feixiong Cheng, Charis Eng
Shape shifting: The multiple conformational substates of the PTEN N-terminal PIP 2 -binding domain. Protein science : a publication of the Protein Society 31 (5) (2022)
Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne D Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, SavaÅŸ Tay, Glenn Randall, Peihui Wang, John T Lis, Cédric Feschotte, Serpil C Erzurum, Feixiong Cheng, Haiyuan Yu
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nature biotechnology (2022)
Muzna Hussain, Alison R Krywanczyk, Eoin Donnellan, Trejeeve Martyn, Ossama Abou Hassan, Saqer Alkharabsheh, Chris Watson, Wai Hong Wilson Tang, Deborah Kwon, Paul C Cremer, Feixiong Cheng, Mohamed Kanj, Brian P Griffin, Carmela D Tan, E Rene Rodriguez, Mazen Hanna, Wael A Jaber, Patrick H Collier
Response by Hussain et al to Letter Regarding Article, "Association Between Atrial Uptake on Cardiac Scintigraphy With Technetium-99m-Pyrophosphate Labeled Bone-Seeking Tracers and Atrial Fibrillation". Circulation. Cardiovascular imaging 15 (9) (2022)
Muzna Hussain, Alison R Krywanczyk, Eoin Donnellan, Trejeeve Martyn, Ossama Abou Hassan, Saqer Alkharabsheh, Chris Watson, Wai Hong Wilson Tang, Deborah Kwon, Paul C Cremer, Feixiong Cheng, Mohamed Kanj, Brian P Griffin, Carmela D Tan, E Rene Rodriguez, Mazen Hanna, Wael A Jaber, Patrick H Collier
Association Between Atrial Uptake on Cardiac Scintigraphy With Technetium-99m-Pyrophosphate Labeled Bone-Seeking Tracers and Atrial Fibrillation. Circulation. Cardiovascular imaging 15 (5) (2022)
Feixiong Cheng, Daniel Geschwind
Human Molecular Genetics Review Issue 2022. Human molecular genetics 31 (R1) (2022)
Yadi Zhou, Jielin Xu, Yuan Hou, James B Leverenz, Asha Kallianpur, Reena Mehra, Yunlong Liu, Haiyuan Yu, Andrew A Pieper, Lara Jehi, Feixiong Cheng
Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment. Alzheimer's research & therapy 13 (1) (2021)
Yadi Zhou, Jiansong Fang, Lynn M Bekris, Young Heon Kim, Andrew A Pieper, James B Leverenz, Jeffrey Cummings, Feixiong Cheng
AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer's drug discovery. Alzheimer's research & therapy 13 (1) (2021)
Yuan Hou, Yadi Zhou, Muzna Hussain, G Thomas Budd, Wai Hong Wilson Tang, James Abraham, Bo Xu, Chirag Shah, Rohit Moudgil, Zoran B Popovic, Chris Watson, Leslie Cho, Mina K Chung, Mohamed Kanj, Samir Kapadia, Brian Griffin, Lars G Svensson, Patrick H Collier, Feixiong Cheng
Cardiac risk stratification in cancer patients: A longitudinal patient-patient network analysis. PLoS medicine 18 (8) (2021)
Yadi Zhou, Junfei Zhao, Jiansong Fang, William Martin, Lang Li, Ruth Nussinov, Timothy A Chan, Charis Eng, Feixiong Cheng
My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype. Genome biology 22 (1) (2021)
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lu, Zehui Liu, Yadi Zhou, William R Martin, Ruisheng Wang, Jin Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A Castrillon, Jiansong Fang, Justin D Lathia, Ruth A Keri, Felice C Lightstone, Elliott Marshall Antman, Raúl Rabadán, David E Hill, Charis Eng, Marc Vidal, Joseph Loscalzo
Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nature genetics 53 (3) (2021)
William R Martin, Feixiong Cheng
A rational design of a multi-epitope vaccine against SARS-CoV-2 which accounts for the glycan shield of the spike glycoprotein. Journal of biomolecular structure & dynamics (2021)
Xiangxiang Zeng, Xiang Song, Tengfei Ma, Xiaoqin Pan, Yadi Zhou, Yuan Hou, Zheng Zhang, Kenli Li, George Karypis, Feixiong Cheng
Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning. Journal of proteome research 19 (11) (2020)
William R Martin, Felice C Lightstone, Feixiong Cheng
In Silico Insights into Protein-protein Interaction Disruptive Mutations in the PCSK9-LDLR complex. International journal of molecular sciences 21 (5) (2020)
Xiangxiang Zeng, Siyi Zhu, Weiqiang Lu, Zehui Liu, Jin Huang, Yadi Zhou, Jiansong Fang, Yin Huang, Huimin Guo, Lang Li, Bruce D Trapp, Ruth Nussinov, Charis Eng, Joseph Loscalzo, Feixiong Cheng
Target identification among known drugs by deep learning from heterogeneous networks. Chemical science 11 (7) (2020)
Huiyuan Chen, Feixiong Cheng, Jing Li
iDrug: Integration of drug repositioning and drug-target prediction via cross-network embedding. PLoS computational biology 16 (7) (2020)
Yadi Zhou, Yuan Hou, Jiayu Shen, Reena Mehra, Asha Kallianpur, Daniel A Culver, Michaela U Gack, Samar Farha, Joe Zein, Suzy Comhair, Claudio Fiocchi, Thaddeus S Stappenbeck, Timothy Chan, Charis Eng, Jae U Jung, Lara E Jehi, Serpil Erzurum, Feixiong Cheng
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS biology 18 (11) (2020)
William R Martin, Feixiong Cheng
Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2. Journal of proteome research 19 (11) (2020)
Chuang Liu, Junfei Zhao, Weiqiang Lu, Yao Dai, Jennifer Hockings, Yadi Zhou, Ruth Nussinov, Charis Eng, Feixiong Cheng
Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes. PLoS computational biology 16 (2) (2020)
Jiansong Fang, Andrew A Pieper, Ruth Nussinov, Garam Lee, Lynn Bekris, James B Leverenz, Jeffrey Cummings, Feixiong Cheng
Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing. Medicinal research reviews 40 (6) (2020)
Defne Bayik, Yadi Zhou, Chihyun Park, Changjin Hong, Daniel Vail, Daniel J Silver, Adam Lauko, Gustavo Roversi, Dionysios C Watson, Alice Lo, Tyler J Alban, Mary McGraw, Mia Sorensen, Matthew M Grabowski, Balint Otvos, Michael A Vogelbaum, Craig Horbinski, Bjarne Winther Kristensen, Ahmad M Khalil, Tae Hyun Hwang, Manmeet S Ahluwalia, Feixiong Cheng, Justin D Lathia
Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner. Cancer discovery 10 (8) (2020)
Wenqiang Song, Laura C Kim, Wei Han, Yuan Hou, Deanna N Edwards, Shan Wang, Timothy S Blackwell, Feixiong Cheng, Dana M Brantley-Sieders, Jin Chen
Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Molecular cancer research : MCR 18 (11) (2020)
Chuipu Cai, Pengfei Guo, Yadi Zhou, Jingwei Zhou, Qi Wang, Fengxue Zhang, Jiansong Fang, Feixiong Cheng
Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity. Journal of chemical information and modeling 59 (3) (2019)
Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, Feixiong Cheng
Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers. PLoS computational biology 15 (3) (2019)
He Peng, Xiangxiang Zeng, Yadi Zhou, Defu Zhang, Ruth Nussinov, Feixiong Cheng
A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications. PLoS computational biology 15 (2) (2019)
Chuipu Cai, Jiansong Fang, Pengfei Guo, Qi Wang, Huixiao Hong, Javid Moslehi, Feixiong Cheng
In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers. Journal of chemical information and modeling 58 (5) (2018)
Weiqiang Lu, Xue Yao, Ping Ouyang, Ningning Dong, Dang Wu, Xingwu Jiang, Zengrui Wu, Chen Zhang, Zhongyu Xu, Yun Tang, Shien Zou, Mingyao Liu, Jian Li, Minghua Zeng, Ping Lin, Feixiong Cheng, Jin Huang
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. Journal of medicinal chemistry 60 (5) (2017)
Jiansong Fang, Zengrui Wu, Chuipu Cai, Qi Wang, Yun Tang, Feixiong Cheng
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy. Journal of chemical information and modeling 57 (11) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Feixiong Cheng