Effectiveness and safety of lubiprostone after switching from stimulant laxatives in elderly patients with chronic constipation.

Masaki MaruyamaSuguru MiidaToshihiro SatoTakazumi KimuraAzuma WatanabeHideo WatanabeMasafumi NishizawaKyohei HorikawaTakahiro KajiwaraYusuke KarasawaYuko HasebeKazutaka Nozawa Shuji Terai

Published in: JGH open : an open access journal of gastroenterology and hepatology (2023)

Switching to lubiprostone monotherapy for CC was not associated with significant concerns in short-term spontaneous defecation frequency and safety, but it might affect the efficacy and patient quality of life over 2 weeks. Careful treatment strategies facilitating gradual switching to lubiprostone monotherapy may be needed in patients using stimulant laxatives.

Keyphrases

attention deficit hyperactivity disorder
end stage renal disease
ejection fraction
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combination therapy
open label
prognostic factors
case report
randomized controlled trial
patient reported outcomes
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double blind