Enhanced expression of galectin-9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy.
Cédric LerévérendNour KotaichLucille CartierManon De BoniSarah LahireCaroline FichelCharlotte ThiebaultEva BrabencovaCélia MaquinElodie BarbosaLaurent CorsoisJudicael HottonSofiane GuendouzenPhilippe GuilbertAude-Marie Lepagnol-BestelLaurence Cahen-DoidyJacqueline Lehmann-CheJérôme DevyArmand BensussanSébastien Le JanArnaud PommierYacine MerroucheRichard Le NaourStéphane VignotStéphane PotteauxPublished in: International journal of cancer (2024)
Optimizations are expected in the development of immunotherapy for the treatment of Triple-negative breast cancer (TNBC). We studied the expression of galectin-9 (Gal-9) after irradiation and assessed the differential impacts of its targeting with or without radiotherapy. Tumor resections from TNBC patients who received neoadjuvant radiotherapy revealed higher levels of Gal-9 in comparison to their baseline level, only in non-responder patients. Gal-9 expression was also found to be increased in TNBC tumor biopsies and cell lines after irradiation. We investigated the therapeutic advantage of targeting Gal-9 after radiotherapy in mice. Irradiated 4T1 cells or control non-irradiated 4T1 cells were injected into BALB/c mice. Anti-Gal-9 antibody treatment decreased tumor progression only in mice injected with irradiated 4T1 cells. This proof-of-concept study demonstrates that Gal-9 could be considered as a dynamic biomarker after radiotherapy for TNBC and suggests that Gal-9 induced-overexpression could represent an opportunity to develop new therapeutic strategies for TNBC patients.
Keyphrases
- early stage
- locally advanced
- poor prognosis
- end stage renal disease
- radiation induced
- radiation therapy
- ejection fraction
- chronic kidney disease
- newly diagnosed
- rectal cancer
- high fat diet induced
- prognostic factors
- squamous cell carcinoma
- lymph node
- induced apoptosis
- cell proliferation
- cancer therapy
- drug delivery
- binding protein
- adipose tissue
- high glucose
- insulin resistance
- smoking cessation
- wild type