COVID-19 Infection and Neuropathological Features.
Leonardo Freire-de-LimaAline Miranda ScovinoLeonardo Marques da FonsecaCamilla Cristie Barreto MenezesCarlos Antonio do Nascimento SantosMarco Edilson Freire de LimaDebora Decote-RicardoMatheus Freire-de-LimaKelli Monteiro da CostaJhenifer Santos Dos ReisMarcos André Rodrigues da Costa SantosCelio Geraldo Freire-de-LimaAlexandre MorrotPublished in: Medicines (Basel, Switzerland) (2021)
The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.
Keyphrases
- sars cov
- public health
- respiratory syndrome coronavirus
- single cell
- liver failure
- respiratory failure
- lipopolysaccharide induced
- oxidative stress
- drug induced
- traumatic brain injury
- low grade
- coronavirus disease
- lps induced
- aortic dissection
- cognitive impairment
- inflammatory response
- global health
- hepatitis b virus
- intensive care unit
- brain injury
- high grade
- extracorporeal membrane oxygenation