Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.

Fengjun XuanFumiko YanoDaisuke MoriRyota ChijimatsuYuji MaenoharaHideki NakamotoYoshifumi MoriYuma MakiiTakeshi OichiMakoto Mark TaketoHironori HojoShinsuke OhbaUng-Il ChungSakae TanakaTaku Saito

Published in: Arthritis research & therapy (2019)

We demonstrated that Wnt/β-catenin signaling regulates Prg4 expression in the SFZ of mouse adult articular cartilage, which plays essential roles in the homeostasis of articular cartilage.

Keyphrases

cell proliferation
stem cells
poor prognosis
long non coding rna
childhood cancer