Human induced pluripotent stem cell-derived atrial cardiomyocytes recapitulate contribution of the slowly activating delayed rectifier currents IKs to repolarization in the human atrium.

Muhammed Ikbal SönmezSilvana GoldackElina NurkkalaCarl SchulzBirgit KlampeThomas SchulzeArne HansenThomas Eschenhagen Jussi T Koivumäki Torsten Christ

Published in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)

I Ks exists in hiPSC-aCM with biophysics not different from aCM. As in adult human atrium (SR and AF), IKs does not appear to relevantly contribute to repolarization in hiPSC-aCM.

Keyphrases

endothelial cells
high glucose
induced pluripotent stem cells
pluripotent stem cells
pulmonary artery
signaling pathway
heart failure
inferior vena cava
pulmonary hypertension
oxidative stress
drug induced
left atrial appendage