Individual participant data meta-analysis versus aggregate data meta-analysis: A case study in eczema and food allergy prevention.

Eleanor Van VogtSuzie CroVictoria R CorneliusHywel C WilliamsLisa M AskieRachel PhillipsMaeve M KelleherRobert J Boyle

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)

For this systematic review, IPD did not significantly change primary outcome risk ratios compared with aggregate data meta-analysis. However, certainty of evidence, safety outcomes, subgroup and adherence analyses were significantly different using IPD. This demonstrates benefits of adopting an IPD approach to meta-analysis.

Keyphrases

systematic review
meta analyses
electronic health record
randomized controlled trial
big data
machine learning
adipose tissue
artificial intelligence