Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.

Daniel J Zabransky Yash Chhabra Mitchell E Fane Emma Kartalia James M Leatherman Laura Hüser Jacquelyn W Zimmerman Daniel Delitto Song Han Todd D ArmstrongSoren CharmsazSamantha Guinn Sneha Pramod Elizabeth D Thompson Steven J Hughes Jennifer F O'Connell Josephine M Egan Elizabeth D Thompson Ashani T Weeraratna

Published in: Cancer research (2024)

Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression. See related commentary by Isaacson et al., p. 1185.

Keyphrases

stem cells
extracellular matrix
poor prognosis
cell proliferation