Between-trial heterogeneity in ARDS research.
Jenny JuschtenP R TuinmanT GuoN P JuffermansM J SchultzS A LoerA R J GirbesH J de GroothPublished in: Intensive care medicine (2021)
Among ARDS RCTs in the lung-protective ventilation era, there was large variability in the description of baseline characteristics and significant unexplainable heterogeneity in 28-day control group mortality. These findings signify problems with the generalizability of ARDS research and underline the urgent need for standardized reporting of trial and baseline characteristics.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- phase iii
- study protocol
- single cell
- phase ii
- clinical trial
- respiratory failure
- intensive care unit
- mental health
- cardiovascular events
- randomized controlled trial
- open label
- cardiovascular disease
- double blind
- electronic health record