High expression level of serpin peptidase inhibitor clade E member 2 is associated with poor prognosis in lung adenocarcinoma.

Ryota DokuniTatsuya NaganoNaoe JimboHiroki SatoTatsunori KiriuYuichiro YasudaMasatsugu YamamotoMotoko TachiharaKazuyuki KobayashiYoshimasa ManiwaYoshihiro Nishimura

Published in: Respiratory research (2020)

The overall survival of patients with high SERPINE2 expression was significantly worse than that of patients with low SERPINE2 expression (P = 0.0172). Multivariate analysis revealed that SERPINE2 expression was an independent factor associated with poor prognosis (P = 0.03237). The interference of SERPINE2 decreased cell number and increased apoptosis in A549 and PC9 cells CONCLUSION: These results suggest that SERPINE2 can be used as a novel prognostic marker of lung adenocarcinoma.

Keyphrases

poor prognosis
long non coding rna
single cell
oxidative stress
stem cells
cell death
mesenchymal stem cells
cell proliferation
bone marrow