Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma.
Hung-Cheng ChenMeng-Chih LinTsu-Nai WangWen-Feng FangYa-Chun ChangYu-Mu ChenI-Ya ChenMeng-Chih LinMing-Yu YangPublished in: Journal of asthma and allergy (2021)
Our results showed altered expression of circadian clock genes in patients with bronchial asthma and down-regulated PER3 in patients with nocturnal symptoms. Altered expression of circadian clock genes was also observed in asthmatics with or without nocturnal symptoms in well- or not well-controlled subgroups. Combined expression of BMAL1, CKIε, PER3, and TIM could be a potential predictor for bronchial asthma.
Keyphrases
- poor prognosis
- chronic obstructive pulmonary disease
- blood pressure
- lung function
- genome wide
- binding protein
- obstructive sleep apnea
- sleep quality
- long non coding rna
- allergic rhinitis
- risk assessment
- bioinformatics analysis
- physical activity
- climate change
- depressive symptoms
- sleep apnea
- human health
- resting state