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Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma.

Hung-Cheng ChenMeng-Chih LinTsu-Nai WangWen-Feng FangYa-Chun ChangYu-Mu ChenI-Ya ChenMeng-Chih LinMing-Yu Yang
Published in: Journal of asthma and allergy (2021)
Our results showed altered expression of circadian clock genes in patients with bronchial asthma and down-regulated PER3 in patients with nocturnal symptoms. Altered expression of circadian clock genes was also observed in asthmatics with or without nocturnal symptoms in well- or not well-controlled subgroups. Combined expression of BMAL1, CKIε, PER3, and TIM could be a potential predictor for bronchial asthma.
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