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Proanthocyanidins Inhibit Osteoblast Apoptosis via the PI3K/AKT/Bcl-xL Pathway in the Treatment of Steroid-Induced Osteonecrosis of the Femoral Head in Rats.

Hui LiYufei ZhangYangquan HaoPeng XuXingyu WangBin ZhuChao LuKe Xu
Published in: Nutrients (2023)
PACs can inhibit excessive osteoblast apoptosis in SONFH via the PI3K/AKT/Bcl-xL signaling axis and have potential therapeutic effects.
Keyphrases
  • oxidative stress
  • endoplasmic reticulum stress
  • cell cycle arrest
  • cell death
  • diabetic rats
  • bone regeneration
  • weight gain
  • replacement therapy
  • body mass index
  • signaling pathway