The relationship of KRAS expression with KRAS status, prognosis, and tumor-infiltrated T lymphocytes in colorectal cancer.
Yebohao ZhouZiwei ZengZe LiLei RuanHao XieFujin YeLiang HuangHuashan LiuLiang KangPublished in: Therapeutic advances in gastroenterology (2024)
No association was found between KRAS expression and KRAS mutation status in CRC. Higher KRAS expression was indicative of poorer prognosis for CRC patients, except for those with proficient mismatch repair and KRAS wild type. In addition, in patients with dMMR, KRAS expression was associated with a lower density of CD8+ T lymphocytes in tumor tissue.